The two people were fans of the Twilight movie. Part of the popular movie was filmed at the inn and movie fans often stop by to visit, the owners said.
It’s not clear how the fire started or the extent of the damage. A large column of smoke could be seen coming from the building.
Staff members tried to put the fire out with a garden hose, but were not successful.
Deputies said several guests were in the building at the time. A wedding was also scheduled for the afternoon and the guests who had arrived were sent home. A nearby facility offered the host the wedding instead.
The View Point Inn is located near Vista House in the Columbia River Gorge.
The owners told KATU they have insurance, but aren't sure what all it will cover.
They had recently filed for bankruptcy and aren't sure how they'll be able to carry on.
"I love the inn, but I can't do it by myself anymore," said co-owner Geoff Thompson. "If Oregon wants this inn and if people want this inn, everybody's going to have to join in and save it because I just can't do it my myself."
The fire burned through the roof and did extensive damage to the second floor.
"It just went up in smoke, and what was strange is it started low on the roof. It was not up at the top at all," said co-owner Angelo Simione.
The inn was built in 1924 as a stop along the old Columbia Gorge Highway. It's on the National Register of Historic Places and once hosted President Franklin Roosevelt.
"This is devastating," said onlooker Betsy Lee. "This is such a landmark. It's very sad."